Synonyms/Also Known as
Factor I, Fibrinogen Activity, Hypofibrinogenemia Test
PT and INR, PTT, D-dimer, Coagulation Factors, Thrombin Time, hs-CRP
Why get tested?
To investigate a person with a bleeding disorder or a blood clot, to assay the levels of fibrinogen (factor 1) and its functions, to assess the risk of developing a heart disease.
When to get tested?
When there are episodes of bleeding or thrombosis, when Prothrombin Test and/or activated partial thromboplastin time test is prolonged, when there is a family history of hereditary fibrinogen deficiency or abnormality, to evaluate the risk of developing heart disease in a person.
Test preparation needed
No special preparation required
About The Test
How is it used
1. How can fibrinogen levels be reduced?
If fibrinogen levels are increased due to conditions like pregnancy or acute inflammation, they will return to normal levels, when the underlying condition has been resolved. If fibrinogen concentration is increased due to an acquired condition like rheumatoid arthritis, they remain unaltered. If elevated fibrinogen concentrations are increasing the risk of cardiovascular disease, lifestyle changes (reducing cholesterol and raising HDL) may help.
2. How are fibrinogen, d-dimer, and fibrin degradation products (FDP) tests different?
Fibrinogen activity test is used to evaluate the conversion of soluble fibrinogen into insoluble fibrin in the body. Testing for fibrinogen antigen levels measures the total amount of soluble fibrinogen in the blood. D-dimer and FDP test evaluate the fibrinolytic system. Fibrin degradation products (FDP) measures all the fragments of the dissolving clot, while D-dimer is a more specific test that measures the crosslinked and break-down fragments.
3. Can I have hypo or dysfibrinogenemia and be asymptomatic?
Yes. Many people remain asymptomatic with abnormal or low levels of fibrinogen. Hypo or dysfibrinogenemia may not be identified till a person bleeds for a longer duration than expected, after trauma or a surgery, or when coagulation-related tests are performed.