Synonyms/Also Known as
First Trimester Screen
Second Trimester Maternal Serum Screening, hCG Pregnancy, Amniotic Fluid Analysis, Chromosomal analysis, Cell-Free Fetal DNA
Why get tested?
Double marker test is done in pregnancy between 11weeks and 13weeks 6days of gestation. It helps in assessement of chromosomal disorders, such as Down's syndrome or Edward's syndrome etc in the baby. This test helps in detecting any chromosomal abnormalities that might occur post-conception. All the pregnant women are advised to go through this test to ensure that the baby is normal.
When to get tested?
Usually done between 11weeks and 13weeks 6days of pregnancy.
Test preparation needed
No special preparation required
About The Test
How is it used
1. What is Down syndrome?
Down syndrome (trisomy 21) causes mental retardation and developmental problems and can be associated with congenital heart defects, respiratory and hearing problems, leukemia, and thyroid disorders. Down syndrome and other chromosomal abnormalities increase with the increased age of the mother.
2. What is Edwards syndrome?
Edwards syndrome (trisomy 18) is associated with multiple fetal abnormalities and is usually fatal. The frequency of this abnormality is much less than Down syndrome, and as with Down syndrome, its risk increases with the increasing maternal age.
3. I am pregnant will I have both first and second trimester screening performed?
Yes, first trimester screening for chromosome abnormalities includes tests for PAPP-A, hCG and nuchal translucency ultrasound. Second trimester maternal serum screening (triple or quad screen) includes tests for inhibin A and AFP additionally.