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Adreno Corticotrophic Horomone (ACTH), EDTA Plasma

Number of parameters covered 1


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Synonyms/Also Known as


Related tests

Cortisol, ACTH Stimulation Test, Dexamethasone Suppression Test, Androstenedione

Why get tested?

To diagnose adrenal gland problems and pituitary gland diseases (Cushing syndrome, Cushing disease, Addison disease, adrenal tumors, and pituitary tumors).

When to get tested?

When signs and symptoms associated with excess or deficient cortisol production are present. When a hormone imbalance that could be caused by a problem of the pituitary or adrenal glands is suspected.

Sample required


Test preparation needed

No special preparation required, sample should be given before 10 am

About The Test

How is it used
ACTH blood tests are done along with cortisol tests, to detect, diagnose, and monitor therapy of conditions associated with the excessive or deficient production of cortisol in the body. These include: Cushing disease: Associated with excess cortisol production that is due to a benign ACTH-producing tumor in the pituitary gland Cushing syndrome: signs and symptoms associated with excess cortisol. it may be caused due to an adrenal tumor or adrenal hyperplasia, steroid medications, or an ACTH-producing ectopic tumor located outside the pituitary (lungs) Addison disease (primary adrenal insufficiency): decreased production of cortisol due to adrenal gland damage. Secondary adrenal insufficiency: decreased production of cortisol production due to pituitary dysfunction. Hypopituitarism: pituitary damage or dysfunction that results in decreased (or no) hormone production by the pituitary gland, including ACTH production Measuring both ACTH and cortisol levels can help to differentiate and diagnose the above conditions as the levels of ACTH are inversely proportional to the levels of cortisol. If abnormal levels are detected, additional tests are required to confirm the findings and determine the cause.


1. What is Cushing disease and Cushing syndrome?

Cushing disease is caused by a benign tumor of the pituitary gland where there is the excess production of ACTH thus overstimulating the adrenal gland to produce cortisol. Cushing syndrome refers to the signs and symptoms due to excess cortisol in the body, regardless of the cause (steroid hormones intake, adrenal gland tumors, and ACTH-producing ectopic tumors outside the pituitary gland).

2. What is Addison disease?

Addison disease occurs due to damage or destruction of the adrenal cortex where there is lack of cortisol and other adrenal steroids. It is an autoimmune condition.